Dectin-1 / CLEC7A抗体

Dectin-1 / CLEC7A抗体产品信息
免疫原 : Recombinant Mouse Dectin-1 / CLEC7A protein (Catalog#50233-M07H)
Reagents : PE-conjugated rabbit monoclonal antibody
Clone ID : 010
抗体宿主 : Rabbit IgG
Concentration : 10 μl/Test, 0.1 mg/ml
缓冲液 : Aqueous solution containing 0.5% BSA and 0.09% sodium azide
制备方法 : This antibody was obtained from a rabbit immunized with purified, recombinant Mouse Dectin-1 / CLEC7A (rM Dectin-1 / CLEC7A; Catalog#50233-M07H; NP_064392.2; Phe69-Leu244) and conjugated with PE under optimum conditions, the unreacted PE was removed.
Dectin-1 / CLEC7A抗体 Background
C-type lectin domain family 7 member A, also known as Dendritic cell-associated C-type lectin 1, Dectin-1, Beta-glucan receptor, C-type lectin superfamily member 12, BGR, CLECSF12, and CLEC7A, is a single-pass type II membrane protein which contains oneC-type lectin domain. CLEC7A (Dectin-1) belongs to the large family of pattern recognition receptors (PRRs) which recognize conserved pathogen-associated molecular patterns (PAMPs). CLEC7A (Dectin-1) is highly expressed in peripheral blood leukocytes and dendritic cells. It is also detected in spleen, bone marrow, lung, muscle, stomach and placenta. CLEC7A (Dectin-1) is a pattern-recognition receptor that predominantly recognizes beta-glucans from fungi, plants and bacteria. CLEC7A (Dectin-1) is implicated in immunological defenses against pathogens that have beta-glucans. CLEC7A (Dectin-1) was identified as the most important receptor for beta-glucan. Recognition of beta-glucan by CLEC7A (Dectin-1) triggers effective immune response, including phagocytosis and proinflammatory factor production, to eliminate infecting fungi. CLEC7A (Dectin-1) is also involved in the adaptive immune response as well as autoimmune diseases and immune tolerance. CLEC7A (Dectin-1) is a small C-type lectin receptor for fungal cell wall beta-glucan. Its homologues in some species, including mouse and human. The sequence of mouse CLEC7A (Dectin-1) is found to be highly homologous to that of the rat. It possesses essential motifs for the recognition of beta-glucan and signal transduction. Mouse CLEC7A (Dectin-1) plays essential roles in immune responses against fungi.
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