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TAK1/MAP3K7 Antibody

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  • ¥2400
  • PLLABS已认证
  • 加拿大
  • PL0305351
  • 2025年07月13日
  • WB: 1:100-500 E: 1:500-1000 IHC: 1:100-500 IF: 1:100-500
  • Rabbit
  • Hu, Mo, Rat, Chi, Pig, Cow, Hor,
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 免疫原

      Peptide derived from human MAP3K7.

    • 亚型

      Rabbit Polyclonal IgG

    • 形态

      液态

    • 保存条件

      保存于-20℃

    • 克隆性

      多克隆

    • 标记物

      无标记(PLlabs可供应生物素、酶、荧光素标记的抗体)

    • 适应物种

      Hu, Mo, Rat, Chi, Pig, Cow, Hor,

    • 保质期

      按说明书条件可保存1-2年

    • 抗原来源

      见详细说明资料

    • 目录编号

      PL0305351

    • 级别

      超纯

    • 库存

      大量

    • 供应商

      华拓生物

    • 宿主

      Rabbit

    • 应用范围

      WB: 1:100-500 E: 1:500-1000 IHC: 1:100-500 IF: 1:100-500

    • 浓度

      1mg/ml

    • 靶点

      TAK1/MAP3K7

    • 抗体英文名

      TAK1/MAP3K7 Antibody

    • 抗体名

      转化生长因子β活化激酶1

    • 规格

      0.1ml

    产品细节图片1
    TAK1/MAP3K7 Antibody
    Cat#:PL0305351
    Isotype:Rabbit Polyclonal IgG
    Immunogen:Peptide derived from human MAP3K7.
    Purification: Immunogen affinity purified

    Storage Buffer: PBS, pH 7.4(1%BSA and 0.1% Sodium azide)

    Background:
    The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
    Alternate Names:
    MAP3K7; Mitogen-activated protein kinase kinase kinase 7; Transforming growth factor-beta-activated kinase 1; TGF-beta-activated kinase 1; MAP3K 7; MAPKKK7; Mitogen activated protein kinase kinase kinase 7; TAK1; TGF beta activated kinase 1; TGF1a; Transforming growth factor beta activated kinase 1; M3K7_HUMAN; Map3k7; MEKK7; TGF-beta-activated kinase 1; TGF1a; Transforming growth factor-beta-activated kinase 1.
    Specificity Reaction:Hu, Mo, Rat, Chi, Pig, Cow, Hor,
    Application Notes:WB: 1:100-500 E: 1:500-1000 IHC: 1:100-500 IF: 1:100-500
    Storage :
    Store at –20ºC for one year. Avoid repeated freeze-thaw cycles. At 4ºC for 2-3 weeks after reconstituted.

    This product for research use only, not for use in humans, therapeutic or diagnostic procedures.
    PLlabs公司可供应相应抗体的生物素、辣根过氧化物酶、荧光素(FITC、PE、 CY3、 CY5、 CY7、 PE- CY3/5/7)标记抗体,欢迎大家咨询订购。

    产品细节图片2 产品细节图片3 产品细节图片4
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    图标文献和实验
    相关实验
    • ​Cell Metab:西京医院王琳教授团队报道非酒精性脂肪肝炎新靶点

      ,TRIM16 可抑制 JNK-p38 通路的激活。 图片来源:Thermo Fisher TRIM16 促进磷酸化的 TAK1 的蛋白酶体降解TRIM16 又是如何抑制 JNK-p38 通路激活的呢?为了确定 TRIM16 抑制 JNK-p38 通路的具体靶点,作者在肝细胞中过表达 TRIM16,并进行了免疫沉淀 - 质谱(IP-MS)分析。通过整合 IP-MS 和定量泛素组学的结果,作者筛选到 3 个 MAPK 通路成员,其中 TAK1(也叫 MAP3K7)已被证实在 NASH 进展过程中发挥关键

    • Generation of Antibody Molecules Through Antibody Engineering

      been overcome to a large extent using genetic-engineering techniques to produce chimeric mouse/human and completely human antibodies. Such an approach is particularly suitable because of the domain structure of the antibody molecule ( 2 ), where functional

    • The Antibody Molecule

      The importance of antibody molecules was first recognized in the 1890s, when it was shown that immunity to tetanus and diphtheria was caused by antibodies against the bacterial exotoxins (1 ). Around the same time, it was shown that antisera

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