FRA2/FOSL2 Antibody
Cat#:PL0302960
Isotype:Rabbit Polyclonal IgG
Immunogen:Peptide derived from human FRA2.
Purification: Immunogen affinity purified
Storage Buffer: PBS, pH 7.4(1%BSA and 0.1% Sodium azide)
Background:
Fos and Jun dimerize to form Activator Protein 1 (AP1), a transcriptional factor that binds to the 12-O-tetradecanoylphorbol 13 acetate (TPA) response element (TRE) of several cellular and viral genes including human collagenase, metallothionein IIa, stromelysin, interleukin 2, SV40 and polyoma. Fos and Jun contain the 'leucine-zipper' motif that allows for dimerization and an adjacent basic domain required for biological activity. The functionally active form of Fos is in a heterodimer with a member of the Jun family. While Jun family members can form functional homodimers, studies indicate that Fos family members do not self-associate and therefore do not bind DNA on their own.
Alternate Names:
FLJ23306; Fos L2; FOS like antigen 2; Fos related antigen 2; FosL 2; FosL2; FOSL2; FOSL2_HUMAN; FRA 2.
Specificity Reaction:Hu, Mo, Rat, Chi, Dog, Pig, Cow, , Sheep, Guinea Pig
Application Notes:WB: 1:100-500 E: 1:500-1000 IP: 1:20-100 IHC: 1:100-500 IF: 1:100-500
Storage :
Store at –20ºC for one year. Avoid repeated freeze-thaw cycles. At 4ºC for 2-3 weeks after reconstituted.
This product for research use only, not for use in humans, therapeutic or diagnostic procedures.
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