JNJ-31020028,1094873-14-9

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JNJ-31020028

CAS No. : 1094873-14-9

MCE 国际站：JNJ-31020028

产品活性：JNJ-31020028 是一种选择性的以及可透过血脑屏障的 neuropeptide Y Y2 receptor 拮抗剂，对人和老鼠 Y2 受体的 pIC₅₀ 值分别为 8.07 和 8.22。JNJ-31020028 可用于神经疾病的研究。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：Neuropeptide Y Receptor

In Vitro: JNJ-31020028 (0-10 μM) selectively binds with hY2 , rY2 and mY2 with pIC₅₀ values of 8.07, 8.22 and 8.21, respectively.
JNJ-31020028 (0.1 nM-10 μM; 1 hour) inhibits PYY-induced calcium response with a pK_B value of 8.04.

In Vivo: JNJ-31020028 (0-20 mg/kg; s.c. once) affects the level of plasma corticosterone and refeeding result in stressed animals.

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