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- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
GDC-0917
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1446182-94-0
- 规格：
10 mM * 1 mL/2 mg/5 mg/10 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥2174.0 |
|---|---|---|---|
| 规格： | 2 mg | 产品价格： | ￥1166.0 |
| 规格： | 5 mg | 产品价格： | ￥1750.0 |
| 规格： | 10 mg | 产品价格： | ￥2750.0 |
| 规格： | 50 mg | 产品价格： | ￥7500.0 |
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CUDC-427
CAS No. : 1446182-94-0
MCE 国际站：CUDC-427
产品活性：CUDC-427 (GDC-0917) 是一种高效的 IAP 抑制剂，常用于各种癌症的研究。
研究领域：Apoptosis
作用靶点：IAP
In Vitro: GDC-0917 (0.1 nM-10 μM) induces reduction of cIAP1 levels in PBMCs in a concentration-dependent manner showing greater than 80% inhibition at concentrations greater than 0.1 µM (56.5 ng/mL).
In Vivo: GDC-0917 (0.08-16.3 mg/kg) exhibits antitumor activity in a dose dependent manner in the MDA-MB-231-X1.1 Breast Cancer Xenograft, and GDC-0917 is well tolerated, with all dose groups experiencing a <11% decrease in mean body weight. GDC-0917 has low to moderate clearance in the mouse (12.0 mL/min/kg), rat (27.0 mL/min/kg), and dog (15.3 mL/min/kg), and high clearance in the monkey (67.6 mL/min/kg). Oral bioavailability is lowest in monkeys compared with other species.
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文献和实验Point Mutation Detection in the Dystrophin Gene
consists of 79 exons, spliced together in a 14-kb mature RNA (1 ,2 ). The protein coding region spans 11,058 bp, and encodes a 3685 amino acid protein with a mol wt of 427 kDa (2 ). Transcripts have been identified in many nonmuscular tissues, initiated
Duchenne and Becker Muscular Dystrophy
The two forms of dystrophin-associated muscular dystrophies, known as Duchenne and Becker muscular dystrophy (DMD/BMD; OMIM 310200) are caused by genetic defects in the huge DMD gene (79 exons), located at Xp21 and coding for the 427-kDa
DNA-Based Techniques for Detection of Carriers of Duchenne and Becker Muscular Dystrophy
known to date. It harbors 79 exons, which together produce a 14-kb transcript (mRNA) and code for a 427-kDa protein called dystrophin, a muscle-specific protein, which is located underneath the sarcolemma membrane. In DMD, patients’ dystrophin is absent
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