【U1snRNP-68】重组人U1-snRNP 68kDa蛋

【U1snRNP-68】重组人U1-snRNP 68kDa蛋白，Recombinant Human Small Nuclear Ribonucleoprotein 70kDa，SNRNP70

产品名称：【U1snRNP-68】重组人U1-snRNP 68kDa蛋白-Recombinant Human Small Nuclear Ribonucleoprotein 70kDa

产品货号：PRO-445

产品规格：1mg///20ug///5ug

来源宿主：大肠杆菌中重组表达

保存建议：【U1snRNP-68】重组人U1-snRNP 68kDa蛋白-Recombinant Human Small Nuclear Ribonucleoprotein 70kDa Store at 4℃ if entire vial will be used within 2-4 weeks.Store， frozen at -20℃ for longer periods of time.Avoid multiple freeze-thaw cycles.

背景资料：Small nuclear ribonucleoprotein complexes （abbreviated as U-snRNP） are essential for splicing of precursor mRNA molecules. U1-snRNP is the most abundant RNP particle in the nucleus and consists of one small uridylate-rich RNA （U1 RNA） complexed with several proteins: the three 68/70 kDa， A， C polypeptides are unique to the U1-snRNP particle， whereas 7 so-called Sm proteins （B/B’， D1， D2， D3， E， F， G） form a core subparticle that is common to all U-snRNP complexes.Both the U1-specific proteins and the Sm core particle are targets of autoantibodies which classically have been called the RNP and RNP-Sm specificities， respectively. A clean diagnostic distinction of these specificities has been complicated by the biochemical difficulties of producing clean subparticle fractions from native sources. The use of single recombinant proteins as antigenic targets guarantees a much higher sensitivity and specificity and is the only way to determine RNP antibodies sensu stricto without the disturbing influence of Sm antigens； also with single U1 proteins antibodies will be detected which can be missed because of steric hindrance when using the RNP-Sm complex in an assay.Autoantibodies to U1-snRNP are present in 95% of patients with Mixed Connective Tissue Disease （MCTD） and 30% of patients with SLE. Antibodies against the 68/70 kDa protein are known to have a high clinical significance in MCTD patients. The 68/70 kDa nomenclature of this protein refers to the fact that different splice variants of the protein are found in human cells.

点击：【U1snRNP-68】重组人U1-snRNP 68kDa蛋白-Recombinant Human Small Nuclear Ribonucleoprotein 70kDa查看更详细产品说明，更多应用、储存、价格、货期等信息请致电垂询艾美捷科技有限公司。更多prospec公司特色试剂盒、特色抗体以及特色试剂等产品评论，请点击查看艾美捷特色产品中心。

ProSpec 是一家全球著名细胞因子蛋白生产和研发的公司，具有20多年的生产经验，专注于蛋白（重组及合成）生产研发。我们的核心产品包括：干扰素、白介素、骨蛋白、肿瘤坏死因子、成纤维生长因子、瘦素、干细胞因子、催乳素、表皮生长因子、胰岛素样生长因子、神经生长因子、集落刺激因子、激素、酶、病毒抗原以及各种重组蛋白等。领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。

艾美捷科技有限公司，通过提供完整的产品和服务体系、便利的客户关系和供应链管理，为生命科学研究工作者提供整体打包方案。我们的企业的核心价值观:“学习、创新、合作、卓越"。作为一家具有尖端的技术实力、的经营管理水平和完善的市场销售体系的生物高科技企业，总部位于武汉光谷高新技术开发区，服务面向全国。艾美捷科技是集进口试剂、实验室耗材销售、技术服务与合约开发为一体的专业化高科技公司，为用户提供最前沿的专业资讯、完备的产品、整合的解决方案，及优质的物流服务。为了更好的服务客户，公司组建了一支经验丰富的研发团队-艾美捷生物技术中心，进入研发生产阶段，将更优质的产品推荐给国内生物领域的同仁们!