【LDL】人低密度脂蛋白,Low Density Lipop

【LDL】人低密度脂蛋白，Low Density Lipoprotein，LDL

产品名称：【LDL】人低密度脂蛋白-Low Density Lipoprotein

产品货号：PRO-562

产品规格：1gram

来源宿主：人血浆中提取纯化

保存建议：【LDL】人低密度脂蛋白-Low Density LipoproteinHuman LDL although stable at 4℃ for 1 week， should be stored desiccated below -15℃. （short term i.e. < 3 months） and below -70℃ for long term.

背景资料：LDL is a low-density lipoprotein that transports cholesterol and triglycerides from the liver to peripheral tissues. LDL （like all lipoproteins） facilitates the movement of fats and cholesterol within the water based solution of the blood stream. Each natural LDL particle contains a single Apo B-100 molecule （apolipoprotein B-100 is a protein with 4536 amino acid residues） that circulates the fatty acids and keeps them soluble in the aqueous environment. Additionally， the LDL core is highly-hydrophobic， consisting of linoleate （a polyunsaturated fatty acid） and about 1500 esterified cholesterol molecules. This core is enclosed by a shell of phospholipids and unesterified cholesterol in addition to a single copy of B-100 large protein （514 kD）. Even though the LDL particles are approximately 22 nm in diameter and have a mass of about 3 million Daltons， they have a mass and size distribution since the LDL particles contain a varying number of fatty acids. LDL receptors are synthesized and placed in the plasma membrane when a cell requires cholesterol. The LDL receptors scatter freely until they link to clathrin-coated pits. LDL particles in the blood stream attach to these extracellular LDL receptors. The clathrin-coated pits at that time form vesicles that are endocytosed into the cell. Once the clathrin coat is dropped， the vesicles transport the LDL and their receptors to early endosomes， onto late endosomes to lysosomes. At this point the cholesterol esters in the LDL are hydrolysed. The LDL receptors are recovered back to the plasma membrane. Since LDLs convey cholesterol to the arteries and can be retained there by arterial proteoglycans initializing the formation of plaques， increased levels are linked to atherosclerosis， and thus heart attack， stroke， and peripheral vascular disease. And so， cholesterol within LDL lipoproteins is habitually called "bad" cholesterol. This is a misconception since the cholesterol transported on LDL is the same as the one transported on other lipoprotein particles， it is in itself not "bad"， rather it is how and where the cholesterol is being transported， and in what amounts ultimately， which causes adverse effects. HDL / LDL ratio can give an indication of risk for arteriosclerosis.

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ProSpec 是一家全球著名细胞因子蛋白生产和研发的公司，具有20多年的生产经验，专注于蛋白（重组及合成）生产研发。我们的核心产品包括：干扰素、白介素、骨蛋白、肿瘤坏死因子、成纤维生长因子、瘦素、干细胞因子、催乳素、表皮生长因子、胰岛素样生长因子、神经生长因子、集落刺激因子、激素、酶、病毒抗原以及各种重组蛋白等。领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。

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