【肝珠蛋白】人结合珠蛋白,Human Haptoglobin

【肝珠蛋白】人结合珠蛋白，Human Haptoglobin，Haptoglobin

产品名称：【肝珠蛋白】人结合珠蛋白-Human Haptoglobin

产品货号：PRO-558

产品规格：停产

来源宿主：人血浆中提取纯化

保存建议：【肝珠蛋白】人结合珠蛋白-Human HaptoglobinHuman Haptoglobin although stable at room temperature for 3 weeks， should be stored between 2-8℃.

背景资料：Haptoglobin is a glycoprotein which is synthesized in the liver and circulates in the blood. Haptoglobin is produced typically by hepatocytes but also by other tissues: e.g. skin， lung， and kidney. It is a positive acute phase protein that binds free hemoglobin and removes it from the circulation to prevent kidney injury， and iron loss following hemolysis. The haptoglobin-hemoglobin complex is subsequently removed by the reticuloendothelial system （generally the spleen）. As the reticuloendothelial system removes the haptoglobin-hemoglobin complex from the body， haptoglobin levels are reduced in hemolytic anaemias. In the course of binding hemoglobin， haptoglobin sequesters the iron inside hemoglobin， preventing iron-utilizing bacteria from benefitting from hemolysis.Haptoglobin consists of two ?- and two ?-chains， connected by disulfide bonds. Three major haptoglobin phenotypes are known to exist （Hp 1-1， Hp 2-1， and Hp 2-2）. Hp 1-1 is biologically the most effective in binding free hemoglobin and suppressing inflammatory responses associated with free hemoglobin. Hp 2-2 is biologically the least active， and Hp 2-1 is moderately active. Haptoglobin’s molecular mass ranges from 8-200 kDa.Reduced levels can be seen in haemolysis and impaired liver function. High levels are a marker for acute or chronic inflammation. Ahaptoglobinemia or hypohaptoglobinemia are caused by mutations in the haptoglobin gene and/or its regulatory regions. Haptoglobin is also linked to diabetic nephropathy， the incidence of coronary artery disease in type 1 diabetes， Crohn’s disease， inflammatory disease behavior， primary sclerosing cholangitis， susceptibility to idiopathic Parkinson’s disease， and a reduced incidence of Plasmodium falciparum malaria.

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ProSpec 是一家全球著名细胞因子蛋白生产和研发的公司，具有20多年的生产经验，专注于蛋白（重组及合成）生产研发。我们的核心产品包括：干扰素、白介素、骨蛋白、肿瘤坏死因子、成纤维生长因子、瘦素、干细胞因子、催乳素、表皮生长因子、胰岛素样生长因子、神经生长因子、集落刺激因子、激素、酶、病毒抗原以及各种重组蛋白等。领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。

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