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- 详细信息
- 文献和实验
- 技术资料
- 英文名:
Recombinant Human Collagen-3
- 供应商:
艾美捷科技有限公司
- 规格:
10mg&50mg&100mg
【产品形式】:艾美捷为您提供的【Collagen-3】重组人胶原蛋白-3蛋白产品是Sterile Filtered colorless solution. Sterile Filtered colorless solution.
【背景资料】:Collagen, a major component of the extracellular matrix, is a fibrous protein that provides tensile strength to tissues giving them structural integrity. Collagen and its derivative, gelatin, have been widely used in medical, pharmaceutical and consumer products for more than 100 years. The supply of these materials, created from animal remains, is both abundant and inexpensive. However, most formulations are not highly purified and have the potential to cause an inflammatory reaction in some product users. In addition, concerns have been raised over the last several years about the potential for contamination of bovine products with the agent that causes mad cow disease and its human variant, Creutzfeldt-Jakob Disease. Animal collagens are subject to extensive modifications that continue over the life of the molecule in the extracellular space. These differences influence both the extractability of collagens from tissue and the biophysical characteristics of these collagens. As a result, collagens isolated from tissues exhibit significant lot-to-lot variability and, as bulk materials, are often analytically intractable. Products that contain animal-derived collagen can induce potentially harmful inflammatory or immune responses in humans and pose risk of contamination with viruses or prions, potentially life-threatening pathogens. Recombinant collagens are essentially identical to the native collagen protein thereby reducing the risk of inflammation, immune response, and disease as compared to animal-sourced collagen.
以色列ProSpec-Tany公司专注于细菌来源重组蛋白质生产。其独有细菌和哺乳动物表达和蛋白折叠技术使其成为国际一流科研级蛋白供应商。ProSpec-Tany是世界上能提供蛋白种类最多公司之一。领先生产工艺和规模使其可以提供毫克到克级蛋白,价格优于同类公司。作为多家知名品牌代理,艾美捷与ProSpec一起为研究者们提供最好、最新细胞生物学研究工具而不断扩大产品及服务质量。更多特色试剂盒、特色抗体以及特色试剂等产品评论,请点击查看中国生命科学试剂产品评论网站。
点击【Collagen-3】重组人胶原蛋白-3查看更详细产品说明,更多应用、储存、价格、货期等信息请致电400-6800-1454垂询Prospec中国区域授权总代理艾美捷科技有限公司。
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文献和实验Fabrication of a Human Recombinant Collagen-Based Corneal Substitute Using Carbodiimide Chemistry
Human recombinant collagen can be cross-linked with a variety of chemical cross-linking agents. Cross-linking methods can be tuned to confer collagen-based scaffolds with specific physical properties, improved antigenicity and thermal
Recombinant Collagen Trimers from Insect Cells and Yeast
have been unsuccessful, but active recombinant human prolyl 4-hydroxylase has been produced in insect cells and yeast by coexpression of its α- and β-subunits (7 ,7 ). We have recently shown that recombinant human type III collagen with a stable triple helix
,而 AA 大鼠会出现免疫功能紊乱,且缺乏慢性病理过程,有一定的局限性。 2. 胶原诱导的关节炎(CIA) CIA 是 Trentham[5] 等 1977 建立的实验性关节炎动物模型,多种动物的 Ⅱ 型胶原均可引起关节炎,但多用啮齿类和灵长类。CIA 作为一种内源性自身抗原介导自身免疫性疾病,是目前研究 RA 的金标准模型[6]。 造模机制:胶原蛋白(collagen)是细胞外间质成分,分为 Ⅰ 型、Ⅱ 型和 Ⅲ 型,其中 Ⅱ 型胶原大量存在于关节软骨中。当用异源性 Ⅱ 型胶原(如牛 CⅡ 或鸡 CⅡ
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