【B2GP1】重组人β2糖蛋白I,Recombinant H

【B2GP1】重组人β2糖蛋白I，Recombinant Human Apolipoprotein-H, Sf9，APOH sf9

产品名称：【B2GP1】重组人β2糖蛋白I-Recombinant Human Apolipoprotein-H, Sf9

产品货号：PRO-388

产品规格：1mg///20ug///5ug

来源宿主：昆虫Sf9细胞中重组表达

保存建议：【B2GP1】重组人β2糖蛋白I-Recombinant Human Apolipoprotein-H, Sf9Store at 4℃ if entire vial will be used within 2-4 weeks.Store， frozen at -20℃ for longer periods of time.Avoid multiple freeze-thaw cycles.

背景资料：?2 Glycoprotein I （?2 GP I） is a serum protein with a single polypeptide chain consisting of 326 amino acids and having a molecular weight of 50 kDa. The protein is also known by the alternative name Apolipoprotein H （ApoH） which gives an indication of its phospholipid binding function.Since the detection of ?2 Glycoprotein I as a target of antiphospholipid antibodies in 1990 the discussion about the clinical relevance of ?2 GP I is still controversial. It is well established that anticardiolipin antibodies are a very heterogeneous group and that ?2 GP I is only one of several potential targets for anticardiolipin antibodies. Nevertheless it is generally accepted that the binding of ?2 GP I to anionic lipids or surface is essential for the differential detection of anticardiolipin antibodies associated with autoimmune diseases （versus those associated with infectious diseases like syphilis， tuberculosis， AIDS， etc）.The close relationship of ?2 GP I antibodies and cardiolipin antibodies may indicate that the ?2 GP I isotypes have the same clinical relevance as the cardiolipin isotypes， where IgM， IgG and IgA autoantibodies have been observed and are routinely determined diagnostic targets.B2GP1 antibodies and anticardiolipin antibodies can be detected in patients with arterial and venous thrombosis， recurrent fetal loss， thrombosis and SLE. The titers of anticardiolipin and anti-?2 GP I antibodies usually fluctuate sufficiently that they cannot be used for disease monitoring.

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ProSpec 是一家全球著名细胞因子蛋白生产和研发的公司，具有20多年的生产经验，专注于蛋白（重组及合成）生产研发。我们的核心产品包括：干扰素、白介素、骨蛋白、肿瘤坏死因子、成纤维生长因子、瘦素、干细胞因子、催乳素、表皮生长因子、胰岛素样生长因子、神经生长因子、集落刺激因子、激素、酶、病毒抗原以及各种重组蛋白等。领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。

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