产品名称:【HIV-2 gp32生物素】更新HIV-2 gp32,生物素标记-Recombinant HIV-2 gp32, Biotin Labeled
产品货号:HIV-135
产品规格:0.5mg///100ug///1mg
来源宿主:大肠杆菌中重组表达
保存建议:【HIV-2 gp32生物素】更新HIV-2 gp32,生物素标记-Recombinant HIV-2 gp32, Biotin LabeledHIV-2 gp32 Biotin Labeled protein is shipped at ambient temperature. Upon arrival, Store at -20℃ Stable for Five years frozen. One month in solution at room temperature.
背景资料:HIV-1 and HIV-2 appear to package their RNA differently. HIV-1 binds to any appropriate RNA whereas HIV-2 preferentially binds to mRNA which creates the Gag protein itself. This means that HIV-1 is better able to mutate. HIV-2 is transmitted in the same ways as HIV-1: Through exposure to bodily fluids such as blood, semen, tears and vaginal fluids.Immunodeficiency develops more slowly with HIV-2.HIV-2 is less infectious in the early stages of the virus than with HIV-1.The infectiousness of HIV-2 increases as the virus progresses.Major differences include reduced pathogenicity of HIV-2 relative to HIV-1, enhanced immune control of HIV-2 infection and often some degree of CD4-independence. Despite considerable sequence and phenotypic differences between HIV-1 and 2 envelopes, structurally they are quite similar. Both membrane-anchored proteins eventually form the 6-helix bundles from the N-terminal and C-terminal regions of the ectodomain, which is common to many viral and cellular fusion proteins and which seems to drive fusion.HIV-1 gp41 helical regions can form more stable 6-helix bundles than HIV-2 gp41 helical regions however HIV-2 fusion occurs at a lower threshold temperature (25°C), does not require Ca2+ in the medium, is insensitive to treatment of target cells with cytochalasin B, and is not affected by target membrane glycosphingolipid composition.
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