Recombinant Human Spermidine/Spermine N1-Acetyltransferase 1
库存:
100
供应商:
艾美捷科技
CAS号:
查看说明书
规格:
1mg///20ug///5ug
【SAT1】重组人精脒/精胺乙酰转移酶1,Recombinant Human Spermidine/Spermine N1-Acetyltransferase 1,SAT1
产品名称:【SAT1】重组人精脒/精胺乙酰转移酶1-Recombinant Human Spermidine/Spermine N1-Acetyltransferase 1
产品货号:ENZ-433
产品规格:1mg///20ug///5ug
来源宿主:大肠杆菌中重组表达
保存建议:【SAT1】重组人精脒/精胺乙酰转移酶1-Recombinant Human Spermidine/Spermine N1-Acetyltransferase 1人精脒/精胺乙酰转移酶1(SAT1)溶液可以在4℃冷藏保存4周;如果想延长保存时间,建议分装(加载体蛋白如0.1% HSA或 BSA)后置于-18℃冻存.请避免反复冻融.
背景资料:SAT-1 is a member the acetyltransferase family, and is a rate-limiting enzyme in the catabolic pathway of polyamine metabolism. SAT1 catalyzes the acetylation of spermidine and spermine, and is involved in the regulation of the intracellular concentration of polyamines and their transport out of cells. Therefore, SAT-1’s role is essential in polyamine homoeostasis, given that acetylated products are either excreted from the cell or oxidized by acetylpolyamine oxidase. Increased SAT1 activity causes variety of other effects which include pancreatic cells death, obstruction of regenerative tissue growth, behavioral changes, keratosis follicularis spinulosa decalvans(KFSD), and hair loss.Defects in the SAT1 gene are linked to KFSD(keratosis follicularis spinulosa decalvans), which is a rare X-linked disorder affecting the skin and the eye. The KFSD affected men show thickening of the skin of the neck, ears, and extremities, particularly the palms and soles, loss of eyebrows, eyelashes and beard, thickening of the eyelids with blepharitis and ectropion, and corneal degeneration. Even though the majority of the affected families are compatible with an X-linked inheritance, KFSD are found to be clinically and genetically heterogeneous.
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ProSpec 是一家全球著名细胞因子蛋白生产和研发的公司,具有20多年的生产经验,专注于蛋白(重组及合成)生产研发。我们的核心产品包括:干扰素、白介素、骨蛋白、肿瘤坏死因子、成纤维生长因子、瘦素、干细胞因子、催乳素、表皮生长因子、胰岛素样生长因子、神经生长因子、集落刺激因子、激素、酶、病毒抗原以及各种重组蛋白等。领先的生产工艺和规模使其可以提供毫克到克级蛋白,价格优于同类公司。绝大部分产品是天然成熟型蛋白,而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液,ProSpec-Tany绝大部分产品没有添加保护剂或盐,这就对工艺提出了更高的要求。同时,ProSpec-Tany绝大部分产品为冻干粉,因此易于运输和保存。
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