Recombinant Human Tumor Necrosis Factor Receptor Type 2, His Tag
库存:
100
供应商:
艾美捷科技
CAS号:
查看说明书
规格:
1mg///20ug///5ug
【TNFR2】重组人2型肿瘤坏死因子受体,Recombinant Human Tumor Necrosis Factor Receptor Type 2, His Tag,TNFR2
产品名称:【TNFR2】重组人2型肿瘤坏死因子受体-Recombinant Human Tumor Necrosis Factor Receptor Type 2, His Tag
产品货号:CYT-674
产品规格:1mg///20ug///5ug
来源宿主:大肠杆菌中重组表达
保存建议:【TNFR2】重组人2型肿瘤坏死因子受体-Recombinant Human Tumor Necrosis Factor Receptor Type 2, His Tag人2型肿瘤坏死因子受体(TNFR2)溶液可以在4℃冷藏保存2-4周时间;如果想延长保存时间,建议分装后置于-20℃冻存.请避免反复冻融.
背景资料:TNFR2 belongs to the TNF-receptor superfamily. TNFR2 is receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. TNFR2 mediates the majority of the metabolic effects of TNF-alpha. In addition,knockout studies in mice propose a role for TNFR2 in protecting neurons from apoptosis by stimulating antioxidative pathways. TNFR2 expression might have a significant role in the angiogenesis,tumor cell proliferation and metastasis of Invasive micropapillary carcinoma of the breast.There are 2 types of soluble TNF receptors: sTNFR-I and sTNFR-II,which act to neutralize the biological activities of TNF alpha and TNF beta. The levels of these soluble receptors seem to increase as a result of shedding of the extracellular domains of the membrane bound receptors. High levels of soluble TNF receptors are found in the amniotic fluid of pregnant women. TNFR2 and TNFR1 form a heterocomplex which mediates the recruitment of 2 anti-apoptotic proteins,c-IAP1 and c-IAP2,which possess E3 ubiquitin ligase activity. IAPs’ function in TNF-receptor signaling is unknown; nevertheless,c-IAP1 is believed to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2,which mediates anti-apoptotic signals. Oxidative stress promotes TNFR1 and TNFR2 self-interaction,ligand-independent and enhanced ligand-dependent TNF signaling. TNF-a,TNFR1 and TNFR2 have roles in cellular differentiation. TNFR1 and TNFR2 function in cell type-specific renal injury.
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