【EGLN1】小鼠抗人缺氧诱导因子脯氨酰羟化酶2抗体 | M

【产品形式】：艾美捷为您提供的【EGLN1】小鼠抗人缺氧诱导因子脯氨酰羟化酶2抗体可应用于如下实验：ELISA, Western blot 。

【背景资料】：EGLN1 catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex which has a vital role in mammalian oxygen homeostasis. PHD1 (Egln2), PHD-2 (Egln1), and PHD3 (Egln3) belong to the Egln family of proline hydroxylases. The EGLN family that is known to be a cellular oxygen sensor initiates the first step of HIF degradation through the VHL/ubiquitin pathway. PHD1 and PHD2 hydroxylate both proline 402 and proline 564, however PHD3 can only hydroxylate proline 564. Other than HIF, PHD enzymes catalyze the hydroxylation of RNA polymerase subunits and myogenin. The EGLN1 protein functions as a cellular oxygen sensor. Under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event which targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in the EGLN1 gene are linked to erythrocytosis familial type 3 (ECYT3).

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点击【EGLN1】小鼠抗人缺氧诱导因子脯氨酰羟化酶2抗体查看更详细产品说明，更多应用、储存、价格、货期等信息请致电400-6800-1182垂询Prospec中国区域授权总代理艾美捷科技有限公司。