ANGPT1抗体（C末端）|ANGPT1 Antibody

产品名称：ANGPT1抗体（C末端）|ANGPT1 Antibody （CT） （ANGPT1； KIAA0003； Angiopoietin-1）

【产品形式】：艾美捷为您提供的ANGPT1抗体（C末端）产品为无色溶液形式，含有100 ul抗体.该产品浓度为与批次相关，溶解于包含有0.09% （W/V） NaN3的PBS缓冲液中.请在收到该ANGPT1抗体（C末端）产品后，将其置于-20 °C冷冻保存，建议分装使用以避免反复冻融.

【背景资料】：Angiopoietin-1 （Ang-1） is a secreted ligand for Tie-2， a tyrosine-kinase receptor expressed primarily on vascular endothelial cells and early hematopoietic cells. Ang-1/ Tie-2 signaling promotes angiogenesis during the development， remodeling， and repair of the vascular system. Transgenic mice lacking expression of either Ang-1 or Tie-2 fail to develop a fully functional cardiovascular system and die before birth. Postnatally， the angiogenic activity of Ang-1/Tie-2 is required during normal tissue repair and remodeling of the female endometrium in the menstrual cycle. Ang-1/Tie-2 signaling appears to be regulated by Angiopoietin-2 （Ang-2）， a natural antagonist for Tie-2 that exerts its effects through an internal autocrine loop mechanism. In addition to suppressing endothelial cell activation by inhibiting the expression of adhesion and inflammatory molecules， Ang-1 enhances endothelial cell survival and capillary morphogenesis， and lessens capillary permeability. As such， Ang-1 has a potential to become an effective therapeutic agent for treating various endothelium disorders， including several severe human pulmonary diseases. The efficacy of cell-based Ang-1 gene therapy for acute lung injury （ALI） has recently been studied in a rat model of ALI. The results of this study show that such therapy can markedly improve lung condition and suggest that Ang-1 therapy may represent a potential new strategy for the treatment and/or prevention of acute respiratory distress injury （ARDI）， a significant cause of morbidity and mortality in critically ill patients. Recombinant human ANG-1， derived from HeLa cells， is a C-terminal histidine tagged glycoprotein which migrates with an apparent molecular mass of 60.0 – 70.0 kDa by SDS-PAGE under reducing conditions. Sequencing analysis shows N-terminal sequences starting with Ser-20 and with Asp-70 of the 498 amino acid precursor protein.

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关键词：ANGPT1，ANGPT1抗体（C末端）