S100A8抗体（克隆号IMG48M7C7）|S100A8

产品名称：S100A8抗体（克隆号IMG48M7C7）|S100A8 Antibody （Clone IMG48M7C7） （Calgranulin-A， Calprotectin L1L subunit， Cystic fibrosis antigen， CFAG， Leukocyte L1 complex light chain， Migration inhibitory factor-related pro

【产品形式】：艾美捷为您提供的S100A8抗体（克隆号IMG48M7C7）产品为无色溶液形式，含有100 ug抗体.该产品浓度为0.5 mg/ml，溶解于包含有0.05% BSA和0.05%NaN3的PBS缓冲液中.请在收到该S100A8抗体（克隆号IMG48M7C7）产品后，将其置于-20 °C冷冻保存，建议分装使用以避免反复冻融.

【背景资料】：S100A8 is a low-molecular weight member of the S100 family of calcium-binding protein which promotes tumorigenesis. It promotes cell migration and invasion through p38 MAP dependent NF-kappaB activation leading to an increase of MMP2 and MMP12 in gastric cancer. The phagocyte-specific Ca2+-binding S100A8 protein has been proposed as an essential regulator of the plasma membrane NADPH oxidase activity. It is abundantly expressed in the cytosol of neutrophils and is able to form Ca2+-dependent heterocomplexes， with heterotetramers being a probable prerequisite for its biological activities in myeloid cells. S100A8 and S100A9 have been proposed as essential regulators that exert their role through interactions with NADPH oxidase subunits. S100A8 and S100A9 are generally considered proinflammatory. Whereas hypohalous acids generated by activated phagocytes promote novel modifications in murine S100A8 but modifications to human S100A8 are undefined and there is no evidence that these proteins scavenge oxidants in human disease. Oxidized S100A8 was prominent in lungs from patients with asthma and significantly elevated in sputum compared to controls. Results have broad implications for conditions under which hypohalous acid oxidants are generated by activated phagocytes. Identification in human disease of the novel S100A8 Cys derivatives typical of those generated in vitro strongly supports the notion that S100A8 contributes to antioxidant defense during oxidative stress.

BioVision的公司总部在美丽的旧金山湾地区，它是全球生命科学公司的领导者.BioVision在开发和研究细胞凋亡检测分析、代谢检测方面具有 卓越的影响力.包括检测各种检测分析试剂盒、相关特色抗体、重组蛋白及细胞因子和酶等多种产品，以及其他创新的研究工具.其产品覆盖细胞凋亡研究、能量代 谢、细胞/组织蛋白提取、氧化应激与损伤、代谢与肥胖症、细胞增殖与毒性、信号转导、干细胞研究等领域.作为多家知名品牌的中国总代理以及中国区域代理， 艾美捷与BioVision一起为研究者们提供最好、最新的细胞生物学研究工具而不断扩大产品及服务质量.

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关键词：S100A8，S100A8抗体（克隆号IMG48M7C7）