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- 详细信息
- 文献和实验
- 技术资料
- 克隆性:
多克隆
- 抗体英文名:
SIRT1 Antibody (SIRT1, SIR2L1 )
- 规格:
100 ug
产品名称:SIRT1抗体|SIRT1 Antibody (SIRT1, SIR2L1 )
【产品形式】:艾美捷为您提供的SIRT1抗体产品为无色溶液形式,含有100 ug抗体.该产品浓度为与批次相关,溶解于包含有50% 甘油和0.02%NaN3的PBS缓冲液(pH 7.3)中.请在收到该SIRT1抗体产品后,将其置于-20 °C冷冻保存,建议分装使用以避免反复冻融.
【背景资料】:The sirtuins represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs) and have been shown to catalyze a reaction that couples lysine deacetylation to the formation of nicotinamide and O-acetyl-ADP-ribose from NAD+ and the abstracted acetyl group. This SIRT family of genes is highly conserved from prokaryotes to eukaryotes and is involved in diverse processes including transcriptional regulation, cell cycle progression, DNA damage repair and aging. SIRT1 has been shown to be induced by caloric restriction (CR) in several tissues and SIRT1 mediated deacetylase activity attenuates B-amyloid content in the brain during CR. SIRT1 also regulates the p53-dependent DNA damage response pathway by binding to and deacetylating p53.
BioVision的公司总部在美丽的旧金山湾地区,它是全球生命科学公司的领导者.BioVision在开发和研究细胞凋亡检测分析、代谢检测方面具有 卓越的影响力.包括检测各种检测分析试剂盒、相关特色抗体、重组蛋白及细胞因子和酶等多种产品,以及其他创新的研究工具.其产品覆盖细胞凋亡研究、能量代 谢、细胞/组织蛋白提取、氧化应激与损伤、代谢与肥胖症、细胞增殖与毒性、信号转导、干细胞研究等领域.作为多家知名品牌的中国总代理以及中国区域代理, 艾美捷与BioVision一起为研究者们提供最好、最新的细胞生物学研究工具而不断扩大产品及服务质量.
点击:SIRT1抗体,查看更详细产品说明,更多应用、储存、价格、货期等信息请致电400-6800-868垂询BioVision中国区域授权总代理艾美捷科技有限公司。
关键词:SIRT1,SIRT1抗体
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文献和实验Methods to Investigate the Role of SIRT1 in Endothelial Senescence
Sirtuins are a family of proteins with NAD+ -dependent deacetylase or mono-ADP-ribosyltransferase activity. SIRT1, the mammalian ortholog most closely related to Sir2 (the first gene of this family discovered in yeast), exhibits anti
三句话读懂一篇 CNS:长期玩手机,伤脑又折寿;运动、做家务和社交活动可降低痴呆风险
联合在 Nature Immunology 发表研究论文 Deactylation by SIRT1 enables liquid–liquid phase separation of IRF3/IRF7 in innate antiviral immunity。 该研究将发现 SIRT1 介导的 DNA 结合域(DBD)去乙酰化是 IRF3/7 激活的关键步骤,其激活在衰老过程中受到抑制。通过使用 SIRT1 激动剂来改善 IRF3/IRF7 LLPS 的治疗方法,或可逆转老年人的先天
Introduction: Sirtuins in Aging and Diseases
) was proportional to the SIR2 gene dosage. Subsequent studies have shown that SIR2 homologs also slow aging in C. elegans , Drosophila , and mice. An important insight into the function of sirtuins came from the finding that yeast Sir2p and mammalian SIRT1 are NAD
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