Wnt-1 Antibody,wnt1,wnt 1,wnt-1,INT 1,INT1,wingless type MMTV integration site family member 1
规格:
100 ug
产品名称:Wnt-1抗体|Wnt-1 Antibody,wnt1,wnt 1,wnt-1,INT 1,INT1,wingless type MMTV integration site family member 1
【产品形式】:艾美捷为您提供的Wnt-1抗体产品为100 ug 无色溶液,其浓度为0.5 mg/ml,溶解于包含有30%甘油, 0.5% BSA和0.01%硫柳汞的PBS (pH 7.2)缓冲液中.请将该Wnt-1抗体产品置于-20 ℃冷冻保存,建议分装使用以避免反复冻融.
【背景资料】:Wnt-1 is a secreted protein that signals through the Frizzled family of cell surface receptors and is required for normal embryonic development. Wnt-1 activation induces a complex signaling cascade that ultimately leads to the increased expression of over fifty genes. An important component of Wnt-1 signaling is the stabilization, and resulting accumulation, of the intracellular signaling protein, beta-catenine. Wnt signaling induces and maintains the transformed phenotype and, in certain embryonic cell lines, supports self renewal in the absence of significant differentiation. Elevated levels of Wnt proteins are associated with tumorigenesis and are present in numerous human breast cancers. Mature human Wnt-1 is a glycosylated protein containing 343 amino acid residues.