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- 克隆性:
多克隆
- 抗体英文名:
PKG Antibody,cGKI alpha CGKI cGKI beta cGMP dependent protein kinase 1alpha isozyme cGMP dependent protein kinase 1beta isozyme KGPB PRKG1 PR
- 规格:
100 ug
产品名称:PKG抗体 |PKG Antibody,cGKI alpha CGKI cGKI beta cGMP dependent protein kinase 1alpha isozyme cGMP dependent protein kinase 1beta isozyme KGPB PRKG1 PR
【产品形式】:艾美捷为您提供的PKG抗体 产品为100 ug 无色溶液,其浓度为0.5 mg/ml,溶解于包含有30%甘油, 0.5% BSA和0.01%硫柳汞的PBS缓冲液中.请将该PKG抗体 产品置于-20 ℃冷冻保存,建议分装使用以避免反复冻融.
【背景资料】:PKGs are cyclic GMP-dependent protein kinases (also designed cGKs) that are classified into two types, PKGI and PKGII. Studies have shown that cGKs and cyclic AMP-dependent kinases (cAKs) are highly homologous protein kinase families with similar substrate specificities. Phosphorylation of cellular proteins by both families of kinases leads to alterations in calcium mobilization, protein phosphatase activity, ion channel function, gene transcription, smooth muscle contractility and platelet aggregation. However, recent studies using mice deficient in PKGs have shown that cGMP kinases regulate very specifically distinct pathways which are separate from those used by cyclic AMP kinases.
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点击:PKG抗体 ,查看更详细产品说明,更多应用、储存、价格、货期等信息请致电400-6800-868垂询BioVision中国区域授权总代理艾美捷科技有限公司。
关键词:PKG,PKG抗体
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文献和实验Methods for Identification of cGKI Substrates
The cGMP-dependent protein kinases (cGK), which belong to the family of serine/threonine kinases, exhibit their diverse functions in cells through interaction with a variety of substrate proteins. Several substrates were identified
cGMP-Dependent Protein Kinases (cGK)
cGMP-dependent protein kinases (cGK) are serine/threonine kinases that are widely distributed in eukaryotes. Two genes—prkg1 and prkg2 —code for cGKs, namely, cGKI and cGKII. In mammals, two isozymes, cGKIα and cGKIβ, are generated
Approaches for Monitoring PKG1 Oxidative Activation
cGMP-dependent protein kinase, also known as protein kinase G (PKG), is activated independently of cGMP by a novel thiol-reactive mechanism involving the formation of an intermolecular disulfide. This oxidative modification within PKG
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