【产品形式】:艾美捷为您提供的Phospho-b-Catenin抗体产品为100 ug 无色溶液,其浓度为0.5 mg/ml,溶解于包含有50%甘油, 1% BSA和0.02%硫柳汞的PBS缓冲液中.请将该Phospho-b-Catenin抗体产品置于-20 ℃冷冻保存,建议分装使用以避免反复冻融.
【背景资料】:Catenin is one of the key downstream effectors in the Wnt signaling pathway. It has been implicated to play an important role in early embryonic development and tumorigenesis. β-catenin can be destabilized by GSK-3β or other kinases by phosphorylating it at serines 33, 37, 45 and threonine 41. Mutations of these phosphorylation sites in β-catenin have been found in many tumor cell lines.