【产品形式】:艾美捷为您提供的Livin抗体产品为100 ug 无色溶液,其浓度为0.5 mg/ml,溶解于包含有30%甘油, 0.5% BSA, 0.01%硫柳汞的PBS (pH 7.2)缓冲液中.请将该Livin抗体产品置于-20 ℃冷冻保存,建议分装使用以避免反复冻融.
【背景资料】:Livin is a novel member in the IAP (inhibitor of apoptosis) protein family. Livin contains a single baculoviral IAP repeat (BIR) domain and a RING finger domain and has two isoforms termed Livin-α and Livin-β. Transfection of Livin protected cells from apoptosis induced by FADD, BAX, RIP, RIP3 and DR6. Livin directly reacts with several caspases including Caspase-3, -7, and –9, and it inhibits the activation of caspase-9 induced by Apaf-1, cytochrome c and ATP.