Cathepsin D抗体|Cathepsin D Anti

产品名称：Cathepsin D抗体|Cathepsin D Antibody，CTSD，CLN10，CPSD，MGC2311

【产品形式】：艾美捷为您提供的Cathepsin D抗体产品为100 ug 无色溶液，其浓度为0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA， 0.01%硫柳汞 的PBS （pH 7.2）缓冲液中.请将该Cathepsin D抗体产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.

【背景资料】：Cathepsin D is a normal lysosomal protease that is expressed in all cells. It is an aspartyl protease with a pH optimum in the range of 3-5， and contains two N-linked oligosaccharides. Cathepsin D is synthesized as an inactive 52 kDa pro-enzyme. Activation involves the proteolytic removal of the 43 amino acid profragment and an internal cleavage to generate the two-chain form made up of 34 and 14 kDa subunits. Cathepsin D contains the mannose-6-phosphate lysosomal localization signal that targets the enzyme to the lysosomal compartment where it functions in the normal degradation of proteins. In certain tumor cells， Cathepsin D is abnormally processed and is secreted in its 52 kDa precursor form. Numerous clinical studies as well as in vitro evidence suggest that cathepsin D plays an important role in malignant transformation and may be a useful prognostic indicator for breast cancer.

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关键词：Cathepsin，Cathepsin D抗体