UbcH5b (His标签, C-terminus) | U

【产品形式】：艾美捷为您提供的UbcH5b (His标签, C-terminus)形式为20mM Tris-Cl, pH7.5, 1mM DTT

【背景资料】：UbcH5b, also known as UBE2D2, is a member of the ubiquitin E2 conjugating enzyme family, essential components of the ubiquitin cascade. The selectivity of the ubiquitin cascade for a particular substrate protein relies on the interaction between the E2 conjugating enzyme (of which a cell contains relatively few) and an ubiquitin E3 ligase, of which over 600 have been identified to date. The specific E2-E3 pair required for ubiquitination of a particular substrate protein in vivo may also control the type of ubiquitin modification (mono-, multi-, poly-ubiquitin), the exact substrate lysine residue(s) to be modified and, in the case of polyubiquitination, the chain length and lysine linkage type. UbcH5b is associated with the signal-induced conjugation and subsequent degradation of IκBα in the presence of the SCF complexes (Skp/Cul/F-Box) and with Hdm2 mediated p53 ubiquitination. In vitro UbcH5b acts as a promiscuous E2 and is able to interact with a range of different E3 enzymes and participate in polyubiquitin chain synthesis. Recombinant human UbcH5b protein expressed with a C-terminal His-tag. Protein has utility in ubiquitination reactions, polyubiquitin chain synthesis, identification of substrate specific E2-E3 pairs and determination of E2 polyubiquitin linkage specificity.

英国Viva Bioscience公司是一家研发、生产并销售蛋白降解相关产品的公司。其产品主要用于细胞自噬、泛素化和蛋白酶体研究（也覆盖其他蛋白降解相关的产品），其产品价格合理、质量可靠且具有创新性。目前VIVA Bioscience提供逾460种产品，涉及细胞自噬、蛋白泛素化和讲解相关的所有试剂盒、蛋白、底物以及多种抑制剂、激活剂等全系列产品。作为多家进口品牌的中国区域总代理，艾美捷科技与Viva Bioscience一道为中国科研工作者们提供更好、更新的自噬、泛素化和蛋白酶体等研究工具。

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