UCHL1 蛋白(人) (His标签) | UCHL1 pr

【产品形式】：艾美捷为您提供的UCHL1 蛋白(人) (His标签)形式为50mM Tris-Cl, pH7.5, 1mM DTT

【背景资料】：Ubiquitin C-terminal hydrolases (UCHs) are a family of deubiquitinating enzymes (DUBs) that catalyse the hydrolysis of amides, esters and thioesters of the C-terminus of ubiquitin. Mammalian neuronal cells abundantly express ubiquitin carboxy-terminal hydrolase 1 (UCHL1, also known as PGP9.5). Mutations in UCHL1 are linked to Parkinson's disease as well as gracile axonal dystrophy (gad) in mice. In contrast to the universally expressed UCHL3 isozyme, UCH-L1 is expressed exclusively in neurons and testis/ovary. It has been shown that UCHL1 associates and co-localizes with monoubiquitin and elongates ubiquitin half-life and the suggestion is made that UCHL1, with avidity and affinity for ubiquitin, ensures ubiquitin stability within neurons. Recombinant human UCHL1 protein expressed with a N-terminal His-tag. Exhibits deubiquitinating activity vs. ubiquitin-AMC (VB2906).

英国Viva Bioscience公司是一家研发、生产并销售蛋白降解相关产品的公司。其产品主要用于细胞自噬、泛素化和蛋白酶体研究（也覆盖其他蛋白降解相关的产品），其产品价格合理、质量可靠且具有创新性。目前VIVA Bioscience提供逾460种产品，涉及细胞自噬、蛋白泛素化和讲解相关的所有试剂盒、蛋白、底物以及多种抑制剂、激活剂等全系列产品。作为多家进口品牌的中国区域总代理，艾美捷科技与Viva Bioscience一道为中国科研工作者们提供更好、更新的自噬、泛素化和蛋白酶体等研究工具。

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