GABARAP-L1 蛋白(人) (GST标签) | GAB

【产品形式】：艾美捷为您提供的GABARAP-L1 蛋白(人) (GST标签)形式为50mM Na-phosphate, pH7.5, 150mM NaCl

【背景资料】：Key autophagy protein. Essential for autophagosome biogenesis, particularly elongation and closure. Required for cargo/substrate selection in some forms of selective autophagy. Recombinant human GABARAP-L1 protein expressed with a N-terminal GST-tag. Utility in GABARAP-L1 binding studies and antibody characterisation Background: Autophagy involves concerted action of more than 20 specific autophagy (ATG) proteins that mediate the formation of a double-membrane vesicle, the autophagosome, which engulfs its substrates and delivers them to the lysosome for degradation. In many cases control of substrate selectivity is mediated by ubiquitin modification. The autophagy pathway in mammalian cells is negatively regulated by mammalian target of rapamycin (mTor), inactivation of which leads to initiation of phagophore assembly. Formation and expansion of the pre-autophagosomal structure in yeast requires the attachment of the ubiquitin-like protein ATG8 via its C-terminal glycine to the amino group of phosphatidylethanolamine (PE), enabling its anchoring to the isolation membrane of the autophagosome. In mammals, Atg8 is represented by at least six orthologs that fall into two subgroups, LC3- and GABARAP-like proteins and the free and PE linked versions of these proteins are often referred to as LC3-I and LC3-II respectively.

英国Viva Bioscience公司是一家研发、生产并销售蛋白降解相关产品的公司。其产品主要用于细胞自噬、泛素化和蛋白酶体研究（也覆盖其他蛋白降解相关的产品），其产品价格合理、质量可靠且具有创新性。目前VIVA Bioscience提供逾460种产品，涉及细胞自噬、蛋白泛素化和讲解相关的所有试剂盒、蛋白、底物以及多种抑制剂、激活剂等全系列产品。作为多家进口品牌的中国区域总代理，艾美捷科技与Viva Bioscience一道为中国科研工作者们提供更好、更新的自噬、泛素化和蛋白酶体等研究工具。

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