【背景资料】:mTOR is a serine/threonine protein kinase, belonging to the phosphatidylinositol 3-kinase-related kinase protein family, that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis, and transcription. Negative regulator of autophagy as part of the inhibitory mTOR complex (mTROC1), targeted by rapamycin and other autophagy activitors.