USP13 多克隆抗体 | USP13 polyclonal

【产品形式】：艾美捷为您提供的USP13 多克隆抗体经过WB, ELISA等实验验证。推荐使用稀释比率分别为：WB: 1:500-1000。

【背景资料】：Autophagy and endoplasmic reticulum- associated degradation (ERAD) deubiquitinating enzyme (DUB). Component of a regulatory loop that controls autophagy and p53 levels. Mediates deubiquitination of Beclin-1, a key regulator of autophagy, leading to stabilisation of PIK3C3 / VPS34-containing complexes. Also deubiquitinates USP10, an essential regulator of p53 stability. In turn, PIK3C3 / VPS34- containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3 / VPS34-containing complexes regulate p53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD). Mediates stabilisation of SIAH2 independently of deubiquitinating activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination. Has a weak deubiquitinase activity in vitro and preferentially cleaves 'Lys-63'-linked polyubiquitin chains. In contrast to isopeptidase-T, it is not able to mediate unanchored polyubiquitin disassembly.

英国Viva Bioscience公司是一家研发、生产并销售蛋白降解相关产品的公司。其产品主要用于细胞自噬、泛素化和蛋白酶体研究（也覆盖其他蛋白降解相关的产品），其产品价格合理、质量可靠且具有创新性。目前VIVA Bioscience提供逾460种产品，涉及细胞自噬、蛋白泛素化和讲解相关的所有试剂盒、蛋白、底物以及多种抑制剂、激活剂等全系列产品。作为多家进口品牌的中国区域总代理，艾美捷科技与Viva Bioscience一道为中国科研工作者们提供更好、更新的自噬、泛素化和蛋白酶体等研究工具。

点击USP13 多克隆抗体查看更详细产品说明，更多应用、储存、价格、货期等信息请致电400-6800-868垂询Viva Bioscience中国区域授权总代理艾美捷科技有限公司。