Parkin 单克隆抗体 (PRK8) | Parkin m

【产品形式】：艾美捷为您提供的Parkin 单克隆抗体 (PRK8)经过WB, IP, IF, IHC等实验验证。推荐使用稀释比率分别为：WB 1:200-1000。

【背景资料】：Parkin is a ubiquitin E3 ligase enzyme linked to the development of autosomal recessive forms of Parkinson’s Disease (PD), a process characterised by the loss of dopamine neurons in the substantia nigra region of the brain. It has been demonstrated that Parkin plays a key role in maintaining mitochondrial integrity under stress conditions through the selective ubiquitin mediated degradation of mitochondria by autophagy, also known as mitophagy. During this process Parkin is translocated to damaged or depolarised mitochondria by the mitochondrial kinase PINK1, where it mediates polyubiquitination of various proteins resulting in recruitment of p62 and subsequent targeting for degradation of by autophagic machinery. Parkin mutations identified in PD lead to a decrease or loss of its ubiquitin E3 ligase activity.

英国Viva Bioscience公司是一家研发、生产并销售蛋白降解相关产品的公司。其产品主要用于细胞自噬、泛素化和蛋白酶体研究（也覆盖其他蛋白降解相关的产品），其产品价格合理、质量可靠且具有创新性。目前VIVA Bioscience提供逾460种产品，涉及细胞自噬、蛋白泛素化和讲解相关的所有试剂盒、蛋白、底物以及多种抑制剂、激活剂等全系列产品。作为多家进口品牌的中国区域总代理，艾美捷科技与Viva Bioscience一道为中国科研工作者们提供更好、更新的自噬、泛素化和蛋白酶体等研究工具。

点击Parkin 单克隆抗体 (PRK8)查看更详细产品说明，更多应用、储存、价格、货期等信息请致电400-6800-868垂询Viva Bioscience中国区域授权总代理艾美捷科技有限公司。