Atg9B 多克隆抗体 | Atg9B polyclonal

【产品形式】：艾美捷为您提供的Atg9B 多克隆抗体经过WB等实验验证。推荐使用稀释比率分别为：WB: 1:500-1000。

【背景资料】：Background: Autophagy involves concerted action of more than 20 specific autophagy (ATG) proteins that mediate the formation of a double-membrane vesicle, the autophagosome, which engulfs its substrates and delivers them to the lysosome for degradation. In many cases control of substrate selectivity is mediated by ubiquitin modification. Atg9 transport: Atg9 is the primary transmembrane Atg protein required for autophagosome formation. It is detected in multiple discrete puncta, which probably mark the donor membranes for phagophore expansion. Anterograde movement of Atg9 to the site of vesicle formation, the PAS in yeast, requires Atg11, Atg23 and Atg27. Retrograde movement of Atg9 back to the donor sites involves the Atg1–Atg13 and Atg2–Atg18 complexes. Atg18 and its mammalian homologues, WIPI1 and WIPI2, are recruited to PtdIns3P-marked membranes (the phagophore) by the PtdIns3K complex. In yeast, Atg9 transits through the secretory pathway, and a population is located in reservoirs juxtaposed to mitochondria; in mammalian cells, Atg9B is initially localized to the trans‑Golgi network and is highly expressed in placenta and pituitary gland

英国Viva Bioscience公司是一家研发、生产并销售蛋白降解相关产品的公司。其产品主要用于细胞自噬、泛素化和蛋白酶体研究（也覆盖其他蛋白降解相关的产品），其产品价格合理、质量可靠且具有创新性。目前VIVA Bioscience提供逾460种产品，涉及细胞自噬、蛋白泛素化和讲解相关的所有试剂盒、蛋白、底物以及多种抑制剂、激活剂等全系列产品。作为多家进口品牌的中国区域总代理，艾美捷科技与Viva Bioscience一道为中国科研工作者们提供更好、更新的自噬、泛素化和蛋白酶体等研究工具。

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