Hsp27 单克隆抗体 (6H11) | Hsp27 mon

【产品形式】：艾美捷为您提供的Hsp27 单克隆抗体 (6H11)经过WB, IF等实验验证。推荐使用稀释比率分别为：WB 1:10000, IF 1:1000。

【背景资料】：Human Hsp27 protein, and its mouse homologue Hsp25, are members of the small heat shock protein family (sHsps), comprised of a diverse group of proteins from ~15 to >30kDa. The basic structure of most sHsps is a homologous and highly conserved amino acid sequence, with a α-crystallin domain at the C-terminus and the WD/EPF domain at the less conserved N-terminus. This N-terminus is essential for the development of high molecular oligomers. Hsp27-oligomers consist of stable dimers formed by as many as 8-40 Hsp27 protein monomers . The oligomerisation status is connected with the chaperone activity: aggregates of large oligomers have high chaperone activity, whereas dimers have no chaperone activity. Hsp27 is localized to the cytoplasm of unstressed cells but can redistribute to the nucleus in response to stress, where it may function to stabilise DNA and / or the nuclear membrane. It can be rapidly phosphorylated in response to physiological stimuli and has therefore been suggested to be an important intermediate in second messenger-mediated signaling pathways. Other functions include thermo-tolerance in vivo, inhibition of apoptosis and signal transduction.

英国Viva Bioscience公司是一家研发、生产并销售蛋白降解相关产品的公司。其产品主要用于细胞自噬、泛素化和蛋白酶体研究（也覆盖其他蛋白降解相关的产品），其产品价格合理、质量可靠且具有创新性。目前VIVA Bioscience提供逾460种产品，涉及细胞自噬、蛋白泛素化和讲解相关的所有试剂盒、蛋白、底物以及多种抑制剂、激活剂等全系列产品。作为多家进口品牌的中国区域总代理，艾美捷科技与Viva Bioscience一道为中国科研工作者们提供更好、更新的自噬、泛素化和蛋白酶体等研究工具。

点击Hsp27 单克隆抗体 (6H11)查看更详细产品说明，更多应用、储存、价格、货期等信息请致电400-6800-868垂询Viva Bioscience中国区域授权总代理艾美捷科技有限公司。