p62 多克隆抗体 | p62 polyclonal ant

【产品形式】：艾美捷为您提供的p62 多克隆抗体经过WB等实验验证。推荐使用稀释比率分别为：WB 1:1000-5000。

【背景资料】：The p62 protein functions as a ubiquitin (Ub)-binding scaffold, which regulates a diverse range of signalling pathways leading to activation of the nuclear factor kappa B (NF-κB) family of transcription factors. p62 also plays an important role in the control of induced osteoclastogenesis,and mutations affecting the SQSTM1 gene are commonly found in patients with the skeletal disorder Paget's disease of bone (PDB). The vast majority of the PDB associated mutations identified cluster within the UBA domain, impairing p62's ability to bind Ub and resulting in dysregulated NF-κB signalling. p62 is a critical regulator of the degradation of ubiquitinated proteins by macroautophagy.The p62 protein has a domain structure consistent with its participation in multiple signalling complexes, including a C-terminal Ub-associated (UBA) domain through which p62 binds non-covalently to Ub and a LC3 interacting region (LIR), facilitating simultaneous binding to ubiquitinylated proteins and the autophagic machinery via LC3 / GABARAP. As a result p62 acts as an important substrate receptor for selective autophagy.

英国Viva Bioscience公司是一家研发、生产并销售蛋白降解相关产品的公司。其产品主要用于细胞自噬、泛素化和蛋白酶体研究（也覆盖其他蛋白降解相关的产品），其产品价格合理、质量可靠且具有创新性。目前VIVA Bioscience提供逾460种产品，涉及细胞自噬、蛋白泛素化和讲解相关的所有试剂盒、蛋白、底物以及多种抑制剂、激活剂等全系列产品。作为多家进口品牌的中国区域总代理，艾美捷科技与Viva Bioscience一道为中国科研工作者们提供更好、更新的自噬、泛素化和蛋白酶体等研究工具。

点击p62 多克隆抗体查看更详细产品说明，更多应用、储存、价格、货期等信息请致电400-6800-868垂询Viva Bioscience中国区域授权总代理艾美捷科技有限公司。