Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. [SUBCELLULAR LOCATION] Cell membrane; Multi-pass membrane protein. [TISSUE SPECIFICITY] Parietal cells, pancreas, brain and various neoplastic tissues. [SIMILARITY] Belongs to the G-protein coupled receptor 1 family.
mol wt:50kDa
Other Aliases: Gastrin/cholecystokinin type B receptor; gastrin receptor; cholecystokinin B receptor; Cckbr; CCK2R;CCKR-2; CCK2/gastrin receptor; CCK-B/gastrin receptor