NIK(NF-kappaB-Inducing Kinase; mitogen-activated protein kinase kinase kinase14; MAPKKK14)是一种分布和作用十分广泛的真核细胞转录因子,可被多种细胞外的刺激活化,参与细胞凋亡、炎症等多种条件下的基因调控,具有重要的生理和病理作用。 This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. [provided by RefSeq]. mol wt:104kDa Other Aliases: NF-kappaB-Inducing Kinase; NF kappa beta inducing kinase; HS; HSNIK; NIK; Serine/threonine-protein kinase NIK; mitogen-activated protein kinase kinase kinase 14; MAPKKK14; MAP3K14; FTDCR1B