激酶和磷酸酶(Kinases and Phosphatases) 丝裂原活化蛋白激酶-ERK(Mitogen-activated protein kinase 1, MAPK-1)是一组可以被多种细胞外信号即获得蛋白丝/苏氨酸激酶,处于胞浆信号传导通路的终末位置,活化后转位到核内,作用于核内转录因子,调节基因表达。它主要参与生长因子、激素、细胞因子、应激等各种刺激下细胞的反应、细胞的生长、分化过程。 蛋白分子量:42kDa。 经研究证实,MAPK信号转导通路存在于大多数细胞内,在将细胞外刺激信号转导至细胞及其核内,并引起细胞生物学反应(如细胞增殖、分化、转化及凋亡等)的过程中具有至关重要的作用。研究表明,MAPK信号转导通路在细胞内具有生物进化的高度保守性,在低等原核细胞和高等哺乳类细胞内,目前均已发现存在着多条并行的MAPK信号通路,不同的细胞外刺激可使用不同的MAPK信号通路,通过其相互调控而介导不同的细胞生物学反应。
ERK2 is activated by MEK2, which phosphorylates neighbouring threonine 183 and tyrosine 185 residues. ERK2 is a serine/threonine kinase that phosphorylates MAP2 and myelin basic protein. This kinase is an important proximal componant of the MAP kinase pathway involved in transmitting the signals from growth factors, neurotransmitters and hormones at the cell surface to the transcriptional events in the nucleus. mol wt:42kDa Other Aliases: MAP kinase 2; MAPK 2; P42MAPK; ERK; ERK 2; ERT 1; ERT1; Extracellular Signal Regulated Kinase 2; MAPK 1; MAPK1; MAPK2; Mitogen Activated Protein Kinase 1; Mitogen Activated Protein Kinase 2; P38; P40; P41; P41MAPK; p42 MAPK; PRKM 1; PRKM 2; PRKM1; PRKM2; Protein Tyrosine Kinase ERK2