Recombinant intracellular fragment (aa 97-432) of human Cbp (PAG).
亚型:
IgG
形态:
Liquid
保存条件:
-20°C
克隆性:
Polyclonal
适应物种:
Human, Mouse
宿主:
Rabbit
应用范围:
IP, WB, IHC-P
浓度:
1 mg/ml
靶点:
PAG1
抗体名:
anti-PAG / Cbp antibody
规格:
100 μg
PAG (phosphoprotein associated with GEMs), also known as Cbp (Csk-binding protein), is a ubiquitously expressed 46 kDa transmembrane adaptor protein present in membrane rafts (glycosphingolipid-enriched microdomains), which however migrates on SDS PAGE gels anomalously as an 80 kDa molecule. Following tyrosine phosphorylation by Src family kinases, PAG binds and thereby activates the protein tyrosine kinase Csk, the major negative regulator of the Src family kinases. Signaling via the B-cell receptor in B cells or high affinity IgE receptor (FcepsilonRI) in mast cells leads to PAG increased tyrosine phosphorylation and Csk binding, while T cell receptor signaling causes PAG dephosphorylation, loss of Csk binding and increased activation of the protein tyrosine kinase Lck.