Doccol Made a Difference in Stroke Modeling
Doccol MCAO Sutures Reduce SD to 5% of Its Corresponding Mean Value for Infarction Volume
In the stroke model literature, two types of MCAO models are most frequently used, which are the Koizumi model (Koizumi et al. 1986), and the Longa model (Longa et al. 1989). The Koizumi model suggested the use of silicon rubber-coated monofilaments as occludors whilst the Longa model used flame-blunted monofilaments. It turned out that silicon rubber-coated monofilaments are superior to flame-blunted monofilaments for producing consistent ischemic brain injuries. A study (Tsuchiya et al. 2003) showed that using flame-blunted monofilaments for inducing MCA occlusion caused 40% occurrence of subarachnoid hemorrhage, and the standard deviation for infarction volume was greater than its corresponding mean value. Another technical paper specifically compared the effects of suture types on the infarct consistency and showed that silicon rubber-coated monofilaments were superior to flame-blunted ones, producing consistent infarction; and this was true even with inexperienced surgeons. (Shimamura et al. 2006a) In the mouse intraluminal model, SAH rate could reach 40% if uncoated heat-blunted monofilaments being used; and such a modeling method resulted in the deviation for infarction volume being larger than 50% of its corresponding mean value. (Tsuchiya et al. 2003) The poly-L-Lysine coated monofilament seemed could only increase the mortality (to a rate of 60%), without any benefits for reducing infarct variation. (Huang et al. 1998)
规格标准（大鼠不同体重用不同规格的栓线）
价格，
| Animal Body Weight (g) |
Suggested Diameters (mm) |
Filament USP “0” # |
Available Coating Lengths (mm) |
Using Search Function |
My Special Design subcategories |
| 15-20 |
0.17,0.19 |
70 |
2-10 |
Search “70”, “7017”, “7019” |
“70SPRe” |
| 20-25 |
0.21, 0.22 |
70, 60 |
2-10 |
Search “70”, “60” |
“70SPRe”, “60SP”, and “60SPRe” |
| 25-30 |
0.22, 0.23 |
70, 60 |
2-10 |
Search “70”, “60” |
“70SPRe”, “60SP”, and “60SPRe” |
| 30-35 |
0.23 |
60 |
2-10 |
Search “60” |
“60SP”, and “60SPRe” |
| <200 |
0.31, 0.33, 0.29 |
50 |
2-6* |
Search “50” |
“50SPRe” |
| <200-250 |
0.33, 0.35 |
50, 40 |
2-6* |
Search “50”, “40”; “5033”, “4035” |
“50SPRe”, “40SP”, and “40SPRe” |
| 250-280 |
0.35, 0.37 |
40 |
2-6* |
Search “40”; “4035”, “4037” |
“40SP”, and “40SPRe” |
| 280-330 |
0.37, 0.39 |
40 |
2-6* |
Search “40”; “4037”, “4039” |
“40SP”, and “40SPRe” |
| 330-400 |
0.41 |
40, 30 |
2-6 |
Search “40”, “30” |
“40SP”, “40SPRe”, and “30SP” |
| >400 |
0.43 |
30 |
2-6 |
Search “30” |
“30SP” |
|
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