肿瘤抑制基因p53抗体

英文名称 p53 (DO-1)
中文名称 肿瘤抑制基因p53抗体
别 名 Antigen NY CO 13; Antigen NY-CO-13; Cellular tumor antigen p53; Cys 51 Stop; FLJ92943; HGNC11998; LFS1; p53; p53 antigen; p53 cellular tumor antigen; p53 transformation suppressor; p53 tumor suppressor; P53_HUMAN; Phosphoprotein p53; TP 53; TP53; Transformation related protein 53; TRP53; Tumor protein p53; Tumor suppressor p53; Tumour protein p53.
肿瘤抑制基因p53抗体
说 明 书 0.2ml
研究领域 肿瘤 细胞生物 信号转导 细胞凋亡 细胞周期蛋白 转录调节因子 表观遗传学
抗体来源 Mouse
克隆类型 Monoclonal
交叉反应 Human, Mouse, Rat, Cow, Monkey,
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 53kDa
细胞定位 细胞核 细胞浆
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse p53 (DO-1)
亚 型 IgG2a
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
肿瘤抑制基因p53抗体
产品介绍 background:
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.
肿瘤抑制基因p53抗体
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