Anti-Mouse CD9 FITC

The eBioKMC8 monoclonal antibody reacts with mouse CD9, a 24 kDa member of the
transmembrane 4 superfamily. This family is characterized by the presence of four
hydrophobic domains spanning the cell membrane and short N- and C-terminal cytoplasmic
domains. CD9 is expressed by several cell types including monocytes, macrophages, platelets,
early B cells, activated B and T cells, dendritic cells, eosinophils, basophils, endothelial
cells, myoblasts and neuroblasts. On T cells, CD9 functions as a co-stimulatory molecule
on naïve T cells. Furthermore, CD9 is expressed in oocytes, and CD9-deficiency results
in sterility caused by defective gamete fusion. In mouse macrophages, CD9 functionally
associates with FcγRs to modify signals for phagocytosis and inflammatory responses.
In mouse B cells, it was discovered that CD9 is a marker for marginal zone B cells,
B1 cells, and plasma cells. In dendritic cells, recently it was demonstrated that CD9
facilitates the association of heterologous MHC II molecules. The level of CD9 expression
is subject to donor variability.