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Kartogenin
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KGN
货期:1-2天
MedChemExpress LLC
10 mM * 1 mL/1 mg/5 mg/10 mg/50 mg/100 mg/200 mg
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CAS No. : 4727-31-5
MCE 国际站:Kartogenin
产品活性:Kartogenin (KGN) 是人间充质干细胞分化为软骨细胞的诱导剂,EC50 值为 100 nM。Kartogenin 结合纤维蛋白A,破坏其与转录因子核心结合因子 β 亚基 (CBFβ) 的相互作用,并通过调节 CBFβ-RUNX1 转录程序来诱导软骨形成。Kartogenin 可用于骨关节炎 (OA) 的研究。
研究领域:Stem Cell/Wnt | TGF-beta/Smad
作用靶点:TGF-beta/Smad
In Vitro: Kartogenin (50-5000 nM; 2 weeks) induces the chondrogenetic differentiation of the BMSCs in a concentration-dependent manner.Kartogenin (100 nM; 72 h) induces chondrocyte nodule formation in primary hMSCs.Kartogenin (10 nM-10 μM; 72 h) increases chondrocyte-specific gene expression in hMSCs.Kartogenin (0.12-10 μM; 48 h) inhibits nitric oxide (NO) and glycosaminoglycan (GAG) release induced by cytokines in primary bovine articular chondrocytes.
In Vivo: Kartogenin (10 μM in 4μL of saline; i.a. on days 7 and 21) promotes cartilag erepair in collagenase VII-induced OA models in mice.
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