RUVBL1 Antibody

RUVBL1 Antibody - Product infoApplication
WBPrimary AccessionQ9Y265Other AccessionNP_003698.1ReactivityHumanIsotypeIgG1Clone Names507CT2.2.2Calculated MW50228
DaRUVBL1 Antibody - Additional infoGene ID8607Other Names
RUVBL1; INO80H; NMP238; TIP49; TIP49A; RuvB-like 1; 49 kDa TATA box-binding protein-interacting protein; 54 kDa erythrocyte cytosolic protein; INO80 complex subunit H; Nuclear matrix protein 238;
Pontin 52; TIP49a; TIP60-associated protein 54-alphaTarget/Specificity
Purified His-tagged RUVBL1 protein(Fragment) was used to produced this monoclonal antibody.Dilution
WB~~1:100~500Format
Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a
protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to
prevent freeze-thaw cycles.Precautions
RUVBL1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.RUVBL1 Antibody -
Protein InformationNameRUVBL1SynonymsINO80H, NMP238, TIP49, TIP49AFunction
Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (3' to 5') activity; hexamerization is thought to
be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity. Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May be able to bind plasminogen at cell surface and enhance plasminogen activation.Cellular Location
Nucleus matrix. Nucleus, nucleoplasm. Cytoplasm. Membrane. Cytoplasm, cytoskeleton, microtubule organizing center,
centrosome. Note=Mainly localized in the nucleus, associated with nuclear matrix or in the nuclear cytosol, although it is also present in the cytoplasm and associated with the cell membranes. In prophase and prometaphase it is located at the centrosome and the branching microtubule spindles. After mitotic nuclear membrane disintigration it accumulates at the centrosome and sites of tubulin polymerization. As cells pass through metaphase and into telophase it is located close to the centrosome at the early phase of tubulin polymerization. In anaphase it accumulates at the zone of tubule interdigitation. In telophase it is found at polar tubule overlap, and it reappears at the site of chromosomal decondensation in the daughter cellsTissue Location
Ubiquitously expressed with high expression in heart, skeletal muscle and testis