- ¥1100
- ABGENT
- AM1485a
- 2026年01月12日
- WB IHC IF
- H
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- 详细信息
- 文献和实验
- 技术资料
- 抗体名：
LIN28A Antibody
- 抗体英文名：
LIN28A Antibody
- 应用范围：
WB IHC IF
- 适应物种：
H
- 克隆性：
多克隆
- 规格：
100UL
WB, IHC, IFPrimary AccessionQ9H9Z2ReactivityHumanIsotypeIgG1 KappaClone Names55CT58.12.1Calculated MW22743 DaLIN28A Antibody - Additional infoGene ID79727Other Names
LIN28A; CSDD1; LIN28; ZCCHC1; Protein lin-28 homolog A; Zinc finger CCHC domain-containing protein 1Target/Specificity
LIN28A recombinant protein is used to produce this monoclonal antibody.Dilution
WB~~1:200~2000
IHC~~1:50~200
IF~~1:10~50Format
Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.Storage
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.Precautions
LIN28A Antibody is for research use only and not for use in diagnostic or therapeutic procedures.LIN28A Antibody - Protein InformationNameLIN28ASynonymsCSDD1, LIN28, ZCCHC1Function
Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression (By similarity). Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let- 7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre- let-7 in embryonic stem (ES) cells contributes to the maintenance of ES cells. In contrast, LIN28A down-regulation in neural stem cells by miR-125, allows the processing of pre-let-7. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation.Cellular Location
Cytoplasm. Nucleus, nucleolus. Note=Nucleolar localization observed in 10-15% of the nuclei in differentiated myotubes (By similarity). Shuttles between the cytoplasm and the nucleus. Localizes to cytoplasmic processing bodies and stress granulesTissue Location
Expressed in embryonic stem cells (ES cells), placenta and testis
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文献和实验Generation of Antibody Molecules Through Antibody Engineering
been overcome to a large extent using genetic-engineering techniques to produce chimeric mouse/human and completely human antibodies. Such an approach is particularly suitable because of the domain structure of the antibody molecule ( 2 ), where functional
The importance of antibody molecules was first recognized in the 1890s, when it was shown that immunity to tetanus and diphtheria was caused by antibodies against the bacterial exotoxins (1 ). Around the same time, it was shown that antisera
General comments: Antibodies, like most proteins, do not like to be freeze-thawed. Avoid repetitive freezing of your solution. The best way to store your antibody is to keep a high protein concentration (>1 mg/ml), add some protease
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