- ¥1100
- ABGENT
- AP1633a
- 2026年01月07日
- WB IHC
- H
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- 详细信息
- 文献和实验
- 技术资料
- 抗体名：
SIGLEC7 (D-siglec) Antibody (N-term)
- 抗体英文名：
SIGLEC7 (D-siglec) Antibody (N-term)
- 应用范围：
WB IHC
- 适应物种：
H
- 克隆性：
多克隆
- 规格：
100UL
WB, IHCPrimary AccessionQ9Y286Other AccessionQ9NZQ1ReactivityHumanIsotypeRabbit IgCalculated MW51143 DaSIGLEC7 (D-siglec) Antibody (N-term) - Additional infoGene ID27036Other Names
SIGLEC7; AIRM1; Sialic acid-binding Ig-like lectin 7; Adhesion inhibitory receptor molecule 1; CDw328; D-siglec; QA79 membrane protein; p75; CD_antigen=CD328; Flags: PrecursorTarget/Specificity
This SIGLEC7 (D-siglec) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human SIGLEC7 (D-siglec).Dilution
WB~~1:1000
IHC~~1:50~100Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.Storage
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.Precautions
SIGLEC7 (D-siglec) Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.SIGLEC7 (D-siglec) Antibody (N-term) - Protein InformationNameSIGLEC7SynonymsAIRM1Function
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).Cellular Location
Membrane; Single-pass type I membrane proteinTissue Location
Predominantly expressed by resting and activated natural killer cells and at lower levels by granulocytes and monocytes. High expression found in placenta, liver, lung, spleen, and peripheral blood leukocytes
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