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Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
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货期：1-2天
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1 mg
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GW311616
CAS No. : 198062-54-3
MCE 国际站：GW311616
产品活性：GW-311616 是高活性，口服生物相容性，长效的人中性白细胞弹性蛋白酶 (HNE) 抑制剂。IC50 为 22 nM，Ki 为 0.31 nM。
研究领域：Metabolic Enzyme/Protease
作用靶点：Elastase
In Vitro: GW-311616 (150 μM; 48 hours) markedly suppresses NE activity in U937 and K562 cells lines.
GW-311616 (20-320 μM; 48 hours; U937 cells) treatment inhibits proliferation and induces apoptosis in leukemia cells.
GW-311616 (150 μM; U937 cells) treatment can increase the protein expression levels of Bax and decrease the expression of Bcl-2.
In Vivo: GW-311616 (2 mg/kg; oral administration) rapidly abolishes the circulation of neutrophil elastase (NE) in dogs, while >90% inhibition is maintained for 4 days. This prolonged effect is independent to be due to penetration of neutrophils in bone marrow by orally administrated GW-311616. GW-311616 has moderate terminal elimination half-life (t1/2) of 1.1 hours and 1.5 hours for dog (2 mg/kg, oral), rat (2 mg/kg, oral), respectively.
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文献和实验/XvA51cOhSC/WDGt54PfIMVZn2htPMqxhcNteaQ+Xvi06efUNY1gF4ONciVjDbYG5/efUagjhEK66pHaiODv+cnfPqpDF0DPeRQC+0t+KMlGnf8gvU3ZqBkxLF++L7yEyYQmcDatWsxdty4yJfCn4v4IIcPHUbr1q3Dr/ETJiAPAT52kYcS14mRwNDBg/CDXF/XWWxKsuDh6emJrh3bo6hxURw6eizjCx6CqJoR+i4ZisKyiGilShq
/fuwJe+rJZ1w2SC/XIZeQ+02bNtmNN9zsLyd8Qp9x5Cwvm04PweKFbOGCn9uhh02zBx54YFffgCjRd+688047/fTTndizz4sHJB/s6RvU5cILzxeWDXteE6og8rw8QcqoI6YwEHQCWn2uhftCRagfYPOdEGP6E7gSh/uLePwiS7jfPKP9+A8EMOHI0OaEOvtfETt1drtZX0XOOlkvqaUe72NMTOO5EuLqNcXRwdRiMFnmmeTtoMl4YEn7UZITYu
设计和合成HCV 5’-NC区和Ｃ区的特异性核酶基因并克隆入真核表达载体pSV2-gpt、CD-Sra中，转染HCV感染的MT-2细胞，用定量PCR方法检测核酶对HCV的抑制作用，结果显示两种核酶对HCV均有抑制作用，抑制率分别为54%和62%，二者联合作用时抑制率达78%[18-19]. 丁型肝炎病毒(HDV)的基因链和抗基因链均具有核酶活性，能催化自我切割和自我连接，他最可能是导致核酶活性的结构. HDV基因组自身裂解位点位于688/689 nt位置上，斧头状核酶就是根据HDV核
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