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| 规格： | 10 mM * 1 mL | 产品价格： | ￥785.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥223.0 |
| 规格： | 5 mg | 产品价格： | ￥446.0 |
| 规格： | 10 mg | 产品价格： | ￥714.0 |
| 规格： | 25 mg | 产品价格： | ￥1200.0 |
| 规格： | 50 mg | 产品价格： | ￥1800.0 |
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NSC 405020
CAS No. : 7497-07-6
MCE 国际站：NSC 405020
产品活性：NSC 405020 是一种特异性 MMP14 抑制剂。NSC 405020 可直接与 MMP14 的 血液结合蛋白结构域相互作用。NSC 405020 可降低全长和活性剪切 Notch3 (NICD3) 的表达。NSC 405020 可用于前庭神经鞘瘤、止血及血栓形成的研究。
研究领域：Metabolic Enzyme/Protease
作用靶点：MMP
In Vitro: NSC 405020 (100 and 1000 μM; 0-30 min) inhibits MMP-14 levels by over 85% with a dose-dependent manner in the plasma sample from vestibular schwannoma group.
?NSC 405020 (50 μM) reduces expression of the full length and active cleaved Notch3 (NICD3) by 42% in the WM852 cells.
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文献和实验Neurosphere and Neural Colony-Forming Cell Assays
), neural stem cells (NSC) are often isolated and studied using a culture system referred to as the neurosphere assay. Since its introduction in 1992, the neurosphere system has been used to isolate, expand, and identify the presence of an NSC population
Methods for Analysis of Brain Tumor Stem Cell and Neural Stem Cell Self-Renewal
Neural stem cells (NSC) self-renew and are multipotent, producing neurons and glia. Recent studies have shown that brain tumors (BT) contain cells that, like NSC, self-renew and are multipotent, producing the different types of cells
Since the discovery of neural stem cells (NSC) in the embryonic and adult mammalian central nervous system (CNS), there have been a growing numbers of tissue culture media and protocols to study and functionally characterize NSCs
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