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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
Ro 13-9904 free acid
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
73384-59-5
- 规格：
10 mM * 1 mL/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥605.0 |
|---|---|---|---|
| 规格： | 100 mg | 产品价格： | ￥550.0 |
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Ceftriaxone
CAS No. : 73384-59-5
MCE 国际站：Ceftriaxone
产品活性：Ceftriaxone (Ro 13-9904 free acid) 是一种广谱 β-内酰胺类三代头孢菌素类抗生素，对多种革兰氏阴性菌和阳性菌有良好的抗菌活性。Ceftriaxone 是 GSK3β 的共价抑制剂，IC50 值为 0.78 mM。Ceftriaxone 是 Aurora B 的抑制剂。Ceftriaxone 具有抗炎、抗肿瘤和抗氧化活性。Ceftriaxone 可用于治疗细菌性感染和脑膜炎的研究。
研究领域：Anti-infection | Stem Cell/Wnt | PI3K/Akt/mTOR | Epigenetics | Cell Cycle/DNA Damage
作用靶点：Bacterial | Antibiotic | GSK-3 | Aurora Kinase
In Vitro: Ceftriaxone (100 μM, 24 h) protects MPP+ treated astrocytes by inhibiting the NF-κB/JNK/c-Jun signaling pathway [3].
Ceftriaxone (500 μM, 24-48 h) effectively inhibits unanchored cell growth in A549, H520 and H1650 lung cancer cells by inhibiting Aurora B.
In Vivo: Ceftriaxone (200 mg/kg Intraperitoneal injection for 6 weeks) improves functional markers and oxidative stress and inflammation parameters in a rat model of D-galactose (DGL) -induced liver and kidney injury.
Ceftriaxone (200, 400 mg/kg, Intraperitoneal injection) has a protective effect on convulsion induced by Pentylenetetrazol (PTZ) and PTZ-related oxidative damage in rats.
Ceftriaxone (100, 200 mg/kg, Intraperitoneal injection) reduces mechanical dysodynia and hyperalgesia by activating GLT-1 in Streptozocin (HY-13753)-induced diabetic rat models.
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文献和实验2.1 头孢噻肟 cefotaxime - 50 36 3.7 0.23 1.1 头孢拉定 cefradine >90 86 14 5.1 0.25 0.77 头孢曲松
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