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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
PNU-200577; 5-Hydroxymethyl Tolterodine
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
207679-81-0
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1082.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥654.0 |
| 规格： | 5 mg | 产品价格： | ￥1440.0 |
| 规格： | 10 mg | 产品价格： | ￥2240.0 |
| 规格： | 25 mg | 产品价格： | ￥3913.0 |
| 规格： | 50 mg | 产品价格： | ￥5600.0 |
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Desfesoterodine
CAS No. : 207679-81-0
MCE 国际站：Desfesoterodine
产品活性：Desfesoterodine (PNU-200577) 是一种有效的，选择性毒蕈碱受体 (mAChR) 拮抗剂，KB 和 pA2 分别为 0.84 nM 和 9.14。Desfesoterodine 是 Tolterodine (PNU-200583; HY-A0024) 和 Fesoterodine (HY-70053) 的主要药理活性代谢产物。Desfesoterodine 改善大鼠脑梗死诱导膀胱过度活动。
研究领域：GPCR/G Protein | Neuronal Signaling
作用靶点：mAChR
In Vitro: In vitro, Desfesoterodine preventes carbachol-induced contraction of guinea-pig isolated urinary bladder strips in a competitive and concentration-dependent manner.
In radioligand binding studies carries out in homogenates of guinea-pig tissues and Chinese hamster ovary cell lines expressing human muscarinic m1-m5 receptors, Desfesoterodine is not selective for any muscarinic receptor subtype.
In Vivo: Desfesoterodine (PNU-200577; 5-Hydroxymethyl Tolterodine; 0.1 and 1 mg/kg; IV) significantly increases bladder compliance after moderate and high doses.
In vivo, Desfesoterodine is significantly more potent at suppressing acetylcholine-induced urinary bladder contraction than electrically induced salivation in the anaesthetised cat (ID50=15 and 40 nmol/kg, respectively) .
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