- ￥1200 - 4440
- MedChemExpress(MCE)
- 美国
- HY-32341
- 2025年12月05日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 保存条件：
4°C, protect from light, stored under nitrogen
- 英文名：
EB 1089
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
134404-52-7
- 规格：
1 mg/5 mg
| 规格： | 1 mg | 产品价格： | ￥1200.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥4440.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
Seocalcitol
CAS No. : 134404-52-7
MCE 国际站：Seocalcitol
产品活性：Seocalcitol 是一种 vitamin D 类似物，作用于人骨肉瘤 MG-63 细胞，结合 vitamin D 受体蛋白，Kd 为 0.27 nM。
研究领域：Vitamin D Related/Nuclear Receptor
作用靶点：VD/VDR
In Vitro: Seocalcitol (EB 1089) is a stimulators of osteoclast recruitment in murine bone marrow cultures, with EC50 at 0.1 nM. Seocalcitol stimulates bone resorption with an estimated EC50 at 0.03 nM. Seocalcitol (EB 1089) elicites a dose-dependent induction of 24-hydroxylase mRNA in the kidney (EC50=0.4±0.13). In the kidney, Kd values for Seocalcitol is 0.48±0.04 nM. However, in the intestine, the Kd for Seocalcitol is 1.43±0.19 nM). Seocalcitol (0.1-10 nM) induces cell differentiation in a dosedependent manner. A higher differentiating activity is observed for 1 nM Seocalcitol (EB 1089) than for 1 nM VD3.
In Vivo: Seocalcitol (EB1089), a synthetic vitamin D analog, exhibits reduced hypercalcemic activity relative to 1,25(OH)2VD3. In another study, long-term intraperitoneal (IP) administration of Seocalcitol at a dose of 0.5 μg/kg body weight every other day in C3H/Sy mice exertes a very strong inhibitory effect on hepatocellular carcinoma (HCC) development. Seocalcitol (EB 1089) is administered daily to postnatal rats from 4 to 12 days of age (P4 to P12) by intraperitoneal injection at either 0.38 or 1.25 μg/kg body weight (BW)/day. Only the highest dose of Seocalcitol (1.25 μg/kg BW) causes a significant reduction in weight gain when administered alone or in conjunction with Dexamethasone, all-trans retinoic acid (RA), or retinoic acid.
相关产品：Drug Repurposing Compound Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | Calcitriol | Calcipotriol | Vitamin D3 | Calcifediol | Tachysterol 3 | Paricalcitol | Vitamin D2 | Ercalcidiol | Alfacalcidol | TEI-9647 | Eldecalcitol | Ercalcitriol | Secalciferol | MeTC7 | Maxacalcitol | VD3-d6 | Inecalcitol | Tacalcitol | Vitamin D4 | ZK168281 | Doxercalciferol | VD2-d3 | 24, 25-Dihydroxy VD2 | 3-O-(2-Aminoethyl)-25-hydroxyvitamin D3 | Calcitetrol
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
