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- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
321674-73-1
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥921.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥237.0 |
| 规格： | 5 mg | 产品价格： | ￥523.0 |
| 规格： | 10 mg | 产品价格： | ￥837.0 |
| 规格： | 50 mg | 产品价格： | ￥3255.0 |
| 规格： | 100 mg | 产品价格： | ￥5115.0 |
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BIBR 1532
CAS No. : 321674-73-1
MCE 国际站：BIBR 1532
产品活性：BIBR 1532 是一种有效的，选择性的 telomerase 非竞争性抑制剂，IC50 值为 100 nM。
研究领域：Cell Cycle/DNA Damage | Apoptosis
作用靶点：Telomerase | Apoptosis
In Vitro: BIBR 1532 non-competitively inhibits telomerase activity. BIBR 1532 inhibits the proliferation of JVM13 leukemia cells with an IC50 of 52 μM, and similar effect also occurs in other leukemia cell lines such as Nalm-1, HL-60, and Jurkat. BIBR 1532 exerts antiproliferative effect on acute myeloid leukemia (AML) with IC50 of 56 μM with no effect on the proliferative capacity of normal hematopoietic progenitor cells. BIBR 1532 (2.5 μM) reduces colony-forming ability, induces telomere length shortening and causes chemotherapeutic sensitization via inhibiting telomerase activity in MCF-7/WT and melphalan-resistant MCF-7/MlnR cell lines. BIBR 1532 is cytotoxic in a dose-dependent manner in T-cell prolymphocytic leukemia (T-PLL). BIBR 1532 in combination with carboplatin (a chemotherapeutic agent) eliminates ovarian cancer spheroid-forming cells in ES2, SKOV3, and TOV112D cell lines.
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文献和实验BIBR1532 that is a selective, non-nucleosidic inhibitor of the catalytic component hTERT. Treatment of cancer cells with this compound leads to progressive telomere shortening, consecutive telomere dysfunction, and finally growth arrest after a lag
Screening of Telomerase Inhibitors
(G-quadruplex-interactive compound), BIBR1532 (non-nucleosidic reverse transcriptase inhibitor), 2′-O-methyl RNA, and peptide nucleic acids (PNAs; hTR antisense oligonucleotides). To determine minimal effective concentrations for telomerase inhibition
Isolation of Human and Mouse Neutrophils Ex Vivo and In Vitro
peroxide, superoxide anion, and nitric oxide. Recent studies have demonstrated a new strategy—so-called neutrophil extracellular traps (NETs) that are able to kill bacteria and fungi in vivo and in vitro (Brinkmann et al., Science 303:1532–1535, 2004
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