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- 2025年07月12日
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- 详细信息
- 技术资料
- 保存条件：
4°C, sealed storage, away from moisture
- 英文名：
HOE 36-801 hydrochloride
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
56776-32-0
- 规格：
10 mM * 1 mL/5 mg/10 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥770.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥700.0 |
| 规格： | 10 mg | 产品价格： | ￥1000.0 |
| 规格： | 50 mg | 产品价格： | ￥3400.0 |
| 规格： | 100 mg | 产品价格： | ￥6100.0 |
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Etifoxine hydrochloride
CAS No. : 56776-32-0
MCE 国际站：Etifoxine hydrochloride
产品活性：Etifoxine hydrochloride是一个非苯二氮卓类的、具有 GABA 能的化合物，是 GABAA 受体亚基 α1β2γ2 和 α1β3γ2 的阳性变构调节剂。Etifoxine hydrochloride 在啮齿类动物中显示出抗焦虑和抗惊厥活性。
研究领域：Membrane Transporter/Ion Channel | Neuronal Signaling
作用靶点：GABA Receptor
In Vitro: Etifoxine (EFX), at concentrations ranging from 10 to 300 μM (higher concentrations limited its solubility), produces a dose-dependent increase in the [3H]muscimol binding at equilibrium, to 155±2% of its control value at 300 μM EFX.
In Vivo: Etifoxine competitively inhibits [35S]TBPS binding with micromolar potency in rat brain.
Etifoxine (3.125-50 mg/kg) exhibits more pronounced anxiolytic and anticonvulsant effects in the BALB/cByJ mice compared to the C57BL/6J mice.
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