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- MedChemExpress(MCE)
- 美国
- HY-16578
- 2025年12月05日
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- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
22978-25-2
- 规格：
10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg/100 mg/500 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥656.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥596.0 |
| 规格： | 10 mg | 产品价格： | ￥900.0 |
| 规格： | 25 mg | 产品价格： | ￥1400.0 |
| 规格： | 50 mg | 产品价格： | ￥1820.0 |
| 规格： | 100 mg | 产品价格： | ￥2320.0 |
| 规格： | 500 mg | 产品价格： | ￥5600.0 |
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GW9662
CAS No. : 22978-25-2
MCE 国际站：GW9662
产品活性：GW9662是有效，选择性的 PPARγ 拮抗剂，IC50值为3.3 nM，比PPARα和PPARδ的选择性高10倍和1000倍。
研究领域：Cell Cycle/DNA Damage | Vitamin D Related/Nuclear Receptor
作用靶点：PPAR
In Vitro: GW9662 inhibits radioligand binding to PPARγ, PPARα, and PPARδ with pIC50s of 8.48±0.27 (IC50=3.3 nM; n=10), 7.49±0.17 (IC50=32 nM; n=9), and 5.69±0.17 (IC50=2000 nM; n=3), respectively. GW9662 has nanomolar IC50 versus PPARγ and is 10- and 600-fold less potent in binding experiments using PPARα and PPARδ, respectively. In cell-based reporter assays, GW9662 is a potent and selective antagonist of full-length PPARγ. Co-treatment with both 50 μM BRL 49653 and 10 μM GW9662 results in statistically lower viable cell numbers after 7 days when compared to treatment with either 50 μM BRL 49653 (P=0.001) or 10 μM GW9662 (P=0.01) alone.
In Vivo: Bone marrow (BM) nucleated cell counts in both BADGE- and GW9662(1 mg/kg, i.p.)-treated mice are significantly higher than counts in the aplastic anemia (AA) group. GW9662 (1 mg/kg, i.p.) largely attenuates the renoprotective effects of Lipopolysaccharide (LPS) in the rat.
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